1jvs
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(New page: 200px<br /><applet load="1jvs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jvs, resolution 2.2Å" /> '''Crystal structure of ...)
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Revision as of 16:29, 20 November 2007
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Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase; a target enzyme for antimalarial drugs
Overview
The key enzyme in the nonmevalonate pathway, 1-deoxy-D-xylulose, 5-phosphate reductoisomerase (DXR), has been shown to be an effective, target of antimalarial drugs. Here we report the crystal structure of DXR, complexed with NADPH and a sulfate ion from Escherichia coli at 2.2 A, resolution. The structure showed the presence of an extra domain, which is, absent from other NADPH-dependent oxidoreductases, in addition to the, conformation of catalytic residues and the substrate binding site. A, flexible loop covering the substrate binding site plays an important role, in the enzymatic reaction and the determination of substrate specificity.
About this Structure
1JVS is a Single protein structure of sequence from Escherichia coli with SO4 and NDP as ligands. Active as 1-deoxy-D-xylulose-5-phosphate reductoisomerase, with EC number 1.1.1.267 Full crystallographic information is available from OCA.
Reference
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding., Yajima S, Nonaka T, Kuzuyama T, Seto H, Ohsawa K, J Biochem (Tokyo). 2002 Mar;131(3):313-7. PMID:11872159
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