1qko

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{{STRUCTURE_1qko| PDB=1qko | SCENE= }}
{{STRUCTURE_1qko| PDB=1qko | SCENE= }}
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'''HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE'''
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===HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE===
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==Overview==
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Bacteriorhodopsin is the simplest known photon-driven proton pump and as such provides a model for the study of a basic function in bioenergetics. Its seven transmembrane helices encompass a proton translocation pathway containing the chromophore, a retinal molecule covalently bound to lysine 216 through a protonated Schiff base, and a series of proton donors and acceptors. Photoisomerization of the all-trans retinal to the 13-cis configuration initiates the vectorial translocation of a proton from the Schiff base, the primary proton donor, to the extracellular side, followed by reprotonation of the Schiff base from the cytoplasm. Here we describe the high-resolution X-ray structure of an early intermediate in the photocycle of bacteriorhodopsin, which is formed directly after photoexcitation. A key water molecule is dislocated, allowing the primary proton acceptor, Asp 85, to move. Movement of the main-chain Lys 216 locally disrupts the hydrogen-bonding network of helix G, facilitating structural changes later in the photocycle.
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(as it appears on PubMed at http://www.pubmed.gov), where 10548112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10548112}}
==About this Structure==
==About this Structure==
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[[Category: Proton pump]]
[[Category: Proton pump]]
[[Category: Retinal protein]]
[[Category: Retinal protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:23:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:47:26 2008''

Revision as of 10:47, 27 July 2008

Image:1qko.png

Template:STRUCTURE 1qko

HIGH RESOLUTION X-RAY STRUCTURE OF AN EARLY INTERMEDIATE IN THE BACTERIORHODOPSIN PHOTOCYCLE

Template:ABSTRACT PUBMED 10548112

About this Structure

1QKO is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle., Edman K, Nollert P, Royant A, Belrhali H, Pebay-Peyroula E, Hajdu J, Neutze R, Landau EM, Nature. 1999 Oct 21;401(6755):822-6. PMID:10548112

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