2ilt

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{{Seed}}
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{{STRUCTURE_2ilt| PDB=2ilt | SCENE= }}
{{STRUCTURE_2ilt| PDB=2ilt | SCENE= }}
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'''Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor'''
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===Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor===
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==Overview==
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Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-beta-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.
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The line below this paragraph, {{ABSTRACT_PUBMED_17070044}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17070044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17070044}}
==Disease==
==Disease==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Nadp]]
[[Category: Nadp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:38:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:47:52 2008''

Revision as of 10:47, 27 July 2008

Template:STRUCTURE 2ilt

Contents

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor

Template:ABSTRACT PUBMED 17070044

Disease

Known disease associated with this structure: Cortisone reductase deficiency OMIM:[600713]

About this Structure

2ILT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors., Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT, Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. Epub 2006 Oct 7. PMID:17070044

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