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2h5a

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{{STRUCTURE_2h5a| PDB=2h5a | SCENE= }}
{{STRUCTURE_2h5a| PDB=2h5a | SCENE= }}
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'''Complex of the enzyme PMM/PGM with xylose 1-phosphate'''
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===Complex of the enzyme PMM/PGM with xylose 1-phosphate===
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==Overview==
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Two complexes of the enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from Pseudomonas aeruginosa with a slow substrate and with an inhibitor have been characterized by X-ray crystallography. Both ligands induce an interdomain rearrangement in the enzyme that creates a highly buried active site. Comparisons with enzyme-substrate complexes show that the inhibitor xylose 1-phosphate utilizes many of the previously observed enzyme-ligand interactions. In contrast, analysis of the ribose 1-phosphate complex reveals a combination of new and conserved enzyme-ligand interactions for binding. The ability of PMM/PGM to accommodate these two pentose phosphosugars in its active site may be relevant for future efforts towards inhibitor design.
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(as it appears on PubMed at http://www.pubmed.gov), where 16880541 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16880541}}
==About this Structure==
==About this Structure==
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[[Category: Enzyme-ligand complex]]
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:53:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:48:54 2008''

Revision as of 10:48, 27 July 2008

Image:2h5a.png

Template:STRUCTURE 2h5a

Complex of the enzyme PMM/PGM with xylose 1-phosphate

Template:ABSTRACT PUBMED 16880541

About this Structure

2H5A is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor., Regni C, Shackelford GS, Beamer LJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt, 8):722-6. Epub 2006 Jul 24. PMID:16880541

Page seeded by OCA on Sun Jul 27 13:48:54 2008

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