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1rpb

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[[Image:1rpb.gif|left|200px]]
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{{STRUCTURE_1rpb| PDB=1rpb | SCENE= }}
{{STRUCTURE_1rpb| PDB=1rpb | SCENE= }}
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'''SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS'''
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===SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS===
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==Overview==
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The structure of RP 71955, a new tricyclic 21 amino acid peptide active against human immunodeficiency virus 1, was determined. Its amino acid composition was inferred from the results of fast atom bombardment mass spectrometry, nuclear magnetic resonance, Raman spectroscopy, and amino acid analysis. Its sequence could not be determined classically, using Edman degradation, given the lack of a free terminal NH2. It was deduced from the interpretation of interresidue nuclear Overhauser effects and confirmed by the sequencing of peptides obtained by limited chemical hydrolysis. It was found to be CLGIGSCNDFAGCGYAVVCFW. An internal amide bond between the NH2 of C1 and the gamma-COOH of D9 was observed, as well as two disulfide bridges, one between C1 and C13 and one between C7 and C19. The three-dimensional structure of RP 71955 was determined from nuclear magnetic resonance derived constraints using distance geometry, restrained molecular dynamics, nuclear Overhauser effect back calculation, and an iterative refinement using a full relaxation matrix approach. Analogies between the structure of RP 71955 and some functional domains of gp41, the transmembrane protein of human immunodeficiency virus 1, suggest hypotheses concerning the mode of action of RP 71955.
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(as it appears on PubMed at http://www.pubmed.gov), where 8286361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8286361}}
==About this Structure==
==About this Structure==
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1RPB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA].
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1RPB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Actinomycete_sp9440 Actinomycete sp9440]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPB OCA].
==Reference==
==Reference==
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[[Category: Vuilhorgne, M.]]
[[Category: Vuilhorgne, M.]]
[[Category: Hiv replication inhibitor]]
[[Category: Hiv replication inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:45:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:53:02 2008''

Revision as of 10:53, 27 July 2008

Image:1rpb.png

Template:STRUCTURE 1rpb

SOLUTION STRUCTURE OF RP 71955, A NEW 21 AMINO ACID TRICYCLIC PEPTIDE ACTIVE AGAINST HIV-1 VIRUS

Template:ABSTRACT PUBMED 8286361

About this Structure

1RPB is a Single protein structure of sequence from Actinomycete sp9440. Full experimental information is available from OCA.

Reference

Solution structure of RP 71955, a new 21 amino acid tricyclic peptide active against HIV-1 virus., Frechet D, Guitton JD, Herman F, Faucher D, Helynck G, Monegier du Sorbier B, Ridoux JP, James-Surcouf E, Vuilhorgne M, Biochemistry. 1994 Jan 11;33(1):42-50. PMID:8286361

Page seeded by OCA on Sun Jul 27 13:53:02 2008

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