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2f3k

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{{STRUCTURE_2f3k| PDB=2f3k | SCENE= }}
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'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''
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===Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease===
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==Overview==
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In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.
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{{ABSTRACT_PUBMED_16569872}}
==About this Structure==
==About this Structure==
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[[Category: Ro1]]
[[Category: Ro1]]
[[Category: Substrate envelope]]
[[Category: Substrate envelope]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:25:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:53:45 2008''

Revision as of 10:53, 27 July 2008

Image:2f3k.png

Template:STRUCTURE 2f3k

Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease

Template:ABSTRACT PUBMED 16569872

About this Structure

2F3K is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872

Page seeded by OCA on Sun Jul 27 13:53:45 2008

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