1p9m

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[[Image:1p9m.gif|left|200px]]
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{{Seed}}
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[[Image:1p9m.png|left|200px]]
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{{STRUCTURE_1p9m| PDB=1p9m | SCENE= }}
{{STRUCTURE_1p9m| PDB=1p9m | SCENE= }}
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'''Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex'''
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===Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex===
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==Overview==
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Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The 3.65 angstrom-resolution structure of the extracellular signaling complex reveals a hexameric, interlocking assembly mediated by a total of 10 symmetry-related, thermodynamically coupled interfaces. Assembly of the hexameric complex occurs sequentially: IL-6 is first engaged by IL-6Ralpha and then presented to gp130in the proper geometry to facilitate a cooperative transition into the high-affinity, signaling-competent hexamer. The quaternary structures of other IL-6/IL-12 family signaling complexes are likely constructed by means of a similar topological blueprint.
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The line below this paragraph, {{ABSTRACT_PUBMED_12829785}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12829785 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12829785}}
==About this Structure==
==About this Structure==
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[[Category: Ig domain]]
[[Category: Ig domain]]
[[Category: Interleukin-6]]
[[Category: Interleukin-6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:51:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:57:20 2008''

Revision as of 10:57, 27 July 2008

Image:1p9m.png

Template:STRUCTURE 1p9m

Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex

Template:ABSTRACT PUBMED 12829785

About this Structure

1P9M is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex., Boulanger MJ, Chow DC, Brevnova EE, Garcia KC, Science. 2003 Jun 27;300(5628):2101-4. PMID:12829785

Page seeded by OCA on Sun Jul 27 13:57:20 2008

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