1sbu

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[[Image:1sbu.gif|left|200px]]
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{{STRUCTURE_1sbu| PDB=1sbu | SCENE= }}
{{STRUCTURE_1sbu| PDB=1sbu | SCENE= }}
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'''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2'''
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===NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2===
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==Overview==
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The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.
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The line below this paragraph, {{ABSTRACT_PUBMED_15326523}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15326523 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15326523}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA].
==Reference==
==Reference==
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[[Category: Nmr spectroscopy]]
[[Category: Nmr spectroscopy]]
[[Category: Vi beta turn]]
[[Category: Vi beta turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:31:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:58:49 2008''

Revision as of 10:59, 27 July 2008

Image:1sbu.png

Template:STRUCTURE 1sbu

NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2

Template:ABSTRACT PUBMED 15326523

About this Structure

Full experimental information is available from OCA.

Reference

A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog., Chierici S, Jourdan M, Figuet M, Dumy P, Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:15326523

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