1yim

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1yim.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1yim.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1yim| PDB=1yim | SCENE= }}
{{STRUCTURE_1yim| PDB=1yim | SCENE= }}
-
'''Human estrogen receptor alpha ligand-binding domain in complex with compound 4'''
+
===Human estrogen receptor alpha ligand-binding domain in complex with compound 4===
-
==Overview==
+
<!--
-
The discovery, synthesis, and SAR of chromanes as ER alpha subtype selective ligands are described. X-ray studies revealed that the origin of the ER alpha-selectivity resulted from a C-4 trans methyl substitution to the cis-2,3-diphenyl-chromane platform. Selected compounds from this class demonstrated very potent in vivo antagonism of estradiol in an immature rat uterine weight assay, effectively inhibited ovariectomy-induced bone resorption in a 42 days treatment paradigm, and lowered serum cholesterol levels in ovx'd adult rat models. The best antagonists 8F and 12F also exhibited potent inhibition of MCF-7 cell growth and were shown to be estrogen receptor down-regulators (SERDs).
+
The line below this paragraph, {{ABSTRACT_PUBMED_15745820}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15745820 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15745820}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:21:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:59:32 2008''

Revision as of 10:59, 27 July 2008

Image:1yim.png

Template:STRUCTURE 1yim

Human estrogen receptor alpha ligand-binding domain in complex with compound 4

Template:ABSTRACT PUBMED 15745820

About this Structure

1YIM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs., Tan Q, Blizzard TA, Morgan JD 2nd, Birzin ET, Chan W, Yang YT, Pai LY, Hayes EC, DaSilva CA, Warrier S, Yudkovitz J, Wilkinson HA, Sharma N, Fitzgerald PM, Li S, Colwell L, Fisher JE, Adamski S, Reszka AA, Kimmel D, DiNinno F, Rohrer SP, Freedman LP, Schaeffer JM, Hammond ML, Bioorg Med Chem Lett. 2005 Mar 15;15(6):1675-81. PMID:15745820

Page seeded by OCA on Sun Jul 27 13:59:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yim"
Personal tools