2h7d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2h7d.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2h7d.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2h7d| PDB=2h7d | SCENE= }}
{{STRUCTURE_2h7d| PDB=2h7d | SCENE= }}
-
'''Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide'''
+
===Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide===
-
==Overview==
+
<!--
-
Regulation of integrin affinity (activation) is essential for metazoan development and for many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to integrin beta subunit cytoplasmic domains (tails) causes activation, whereas numerous other PTB-domain-containing proteins bind integrins without activating them. Here we define the structure of a complex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific contacts between talin and the integrin tail required for activation. We used structure-based mutagenesis to engineer talin and beta3 variants that interact with comparable affinity to the wild-type proteins but inhibit integrin activation by competing with endogenous talin. These results reveal the structural basis of talin's unique ability to activate integrins, identify an interaction that could aid in the design of therapeutics to block integrin activation, and enable engineering of cells with defects in the activation of multiple classes of integrins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17218263}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17218263 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17218263}}
==About this Structure==
==About this Structure==
-
2H7D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H7D OCA].
+
2H7D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H7D OCA].
==Reference==
==Reference==
Line 26: Line 30:
[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:57:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:05:13 2008''

Revision as of 11:05, 27 July 2008

Image:2h7d.png

Template:STRUCTURE 2h7d

Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide

Template:ABSTRACT PUBMED 17218263

About this Structure

2H7D is a Protein complex structure of sequences from Gallus gallus. Full experimental information is available from OCA.

Reference

Structural basis of integrin activation by talin., Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID, Cell. 2007 Jan 12;128(1):171-82. PMID:17218263

Page seeded by OCA on Sun Jul 27 14:05:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2h7d"
Personal tools