2roy

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spinqualitylabelsall models 2roy, resolution 2.2Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DINITRO-N-ACETYL-L-THYRONINE

Overview

The molecular structures of two human transthyretin (hTTR, prealbumin), complexes, co-crystallized with thyroxine, (3,5,3',5'-tetraiodo-L-thyronine; T(4)), and with, 3',5'-dinitro-N-acetyl-LL-thyronine (DNNAT), were determined by X-ray, diffraction methods. Crystals of both structures are orthorhombic, space, group P2(1)2(1)2, and have two independent monomers in the asymmetric unit, of the crystal lattice. These structures have been refined to 17.0% for, 8-2.0 A resolution data for the T(4) complex (I), and to R = 18.4% for, 8-2.2 A resolution data for the DNNAT structure (II). This report provides, a detailed description of T(4) binding to wild-type hTTR at 2.0 A, resolution, as well as DNNAT. In both structures, the two independent, hormone-binding sites of the TTR tetramer are ... [(full description)]

About this Structure

2ROY is a [Single protein] structure of sequence from [Homo sapiens] with P28 as [ligand]. This structure superseeds the now removed PDB entry 1ROY. Full crystallographic information is available from [OCA].

Reference

Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution., Wojtczak A, Cody V, Luft JR, Pangborn W, Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):758-65. PMID:15299640

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