1n1i

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{{STRUCTURE_1n1i| PDB=1n1i | SCENE= }}
{{STRUCTURE_1n1i| PDB=1n1i | SCENE= }}
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'''The structure of MSP-1(19) from Plasmodium knowlesi'''
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===The structure of MSP-1(19) from Plasmodium knowlesi===
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==Overview==
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The protozoan parasite Plasmodium causes malaria, with hundreds of millions of cases recorded annually. Protection against malaria infection can be conferred by antibodies against merozoite surface protein (MSP)-1, making it an attractive vaccine candidate. Here we present the structure of the C-terminal domains of MSP-1 (known as MSP-1(19)) from Plasmodium knowlesi. The structure reveals two tightly packed epidermal growth factor-like domains oriented head to tail. In domain 1, the molecule displays a histidine binding site formed primarily by a highly conserved tryptophan. The protein carries a pronounced overall negative charge primarily due to the large number of acidic groups in domain 2. To map protein binding surfaces on MSP-1(19), we have analyzed the crystal contacts in five different crystal environments, revealing that domain 1 is highly preferred in protein-protein interactions. A comparison of MSP-1(19) structures from P. knowlesi, P. cynomolgi, and P. falciparum shows that, although the overall protein folds are similar, the molecules show significant differences in charge distribution. We propose the histidine binding site in domain 1 as a target for inhibitors of protein binding to MSP-1, which might prevent invasion of the merozoite into red blood cells.
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{{ABSTRACT_PUBMED_12493733}}
==About this Structure==
==About this Structure==
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[[Category: Surface antigen]]
[[Category: Surface antigen]]
[[Category: Surface protein]]
[[Category: Surface protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:58:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:09:53 2008''

Revision as of 11:09, 27 July 2008

Image:1n1i.png

Template:STRUCTURE 1n1i

The structure of MSP-1(19) from Plasmodium knowlesi

Template:ABSTRACT PUBMED 12493733

About this Structure

1N1I is a Single protein structure of sequence from Plasmodium knowlesi. Full crystallographic information is available from OCA.

Reference

Structure of the C-terminal domains of merozoite surface protein-1 from Plasmodium knowlesi reveals a novel histidine binding site., Garman SC, Simcoke WN, Stowers AW, Garboczi DN, J Biol Chem. 2003 Feb 28;278(9):7264-9. Epub 2002 Dec 19. PMID:12493733

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