This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1unr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1unr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1unr, resolution 1.25&Aring;" /> '''CRYSTAL STRUCTURE O...)
Next diff →

Revision as of 18:05, 29 October 2007

Image:1unr.gif

1unr, resolution 1.25Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF THE PH DOMAIN OF PKB ALPHA IN COMPLEX WITH A SULFATE MOLECULE

Overview

Protein kinase B (PKB/Akt) is a key regulator of cell growth, proliferation and metabolism. It possesses an N-terminal pleckstrin, homology (PH) domain that interacts with equal affinity with the second, messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2, generated through insulin, and growth factor-mediated activation of phosphoinositide 3-kinase (PI3K)., The binding of PKB to PtdIns(3,4,5)P3/PtdIns(3,4)P2 recruits PKB from the, cytosol to the plasma membrane and is also thought to induce a, conformational change that converts PKB into a substrate that can be, activated by the phosphoinositide-dependent kinase 1 (PDK1). In this study, we describe two high-resolution crystal structures of the PH domain of, PKBalpha in a noncomplexed form and compare this to a new atomic, resolution (0.98 A, ... [(full description)]

About this Structure

1UNR is a [Single protein] structure of sequence from [Homo sapiens] with SO4 as [ligand]. Full crystallographic information is available from [OCA].

Reference

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change., Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM, Biochem J. 2003 Nov 1;375(Pt 3):531-8. PMID:12964941

Page seeded by OCA on Mon Oct 29 20:10:38 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1unr"
Personal tools