2ptv

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{{STRUCTURE_2ptv| PDB=2ptv | SCENE= }}
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'''Structure of NK cell receptor ligand CD48'''
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===Structure of NK cell receptor ligand CD48===
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==Overview==
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Natural killer (NK) cells eliminate virally infected and tumor cells. Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We determined the structure of the complex between the N-terminal domains of mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The complex displayed an association mode related to, yet distinct from, that of the NTB-A dimer. Binding was accompanied by the rigidification of flexible 2B4 regions containing most of the polymorphic residues across different species and receptor isoforms. We propose a model for 2B4-CD48 interactions that permits the intermixing of SLAM receptors with major histocompatibility complex-specific receptors in the NK cell immune synapse. This analysis revealed the basis for heterophilic recognition within the SLAM family.
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==About this Structure==
==About this Structure==
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[[Category: Nk cell receptor]]
[[Category: Nk cell receptor]]
[[Category: X-ray]]
[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:47:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:14:28 2008''

Revision as of 11:14, 27 July 2008

Image:2ptv.png

Template:STRUCTURE 2ptv

Structure of NK cell receptor ligand CD48

Template:ABSTRACT PUBMED 17950006

About this Structure

2PTV is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family., Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA, Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:17950006

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