2rnq

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[[Image:2rnq.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2rnq| PDB=2rnq | SCENE= }}
{{STRUCTURE_2rnq| PDB=2rnq | SCENE= }}
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'''Solution structure of the C-terminal acidic domain of TFIIE alpha'''
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===Solution structure of the C-terminal acidic domain of TFIIE alpha===
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==Overview==
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RNA polymerase II and general transcription factors (GTFs) assemble on a promoter to form a transcription preinitiation complex (PIC). Among the GTFs, TFIIE recruits TFIIH to complete the PIC formation and regulates enzymatic activities of TFIIH. However, the mode of binding between TFIIE and TFIIH is poorly understood. Here, we demonstrate the specific binding of the C-terminal acidic domain (AC-D) of the human TFIIEalpha subunit to the pleckstrin homology domain (PH-D) of the human TFIIH p62 subunit and describe the solution structures of the free and PH-D-bound forms of AC-D. Although the flexible N-terminal acidic tail from AC-D wraps around PH-D, the core domain of AC-D also interacts with PH-D. AC-D employs an entirely novel binding mode, which differs from the amphipathic helix method used by many transcriptional activators. So the binding surface between PH-D and AC-D is much broader than the specific binding surface between PH-D and the p53 acidic fragments. From our in vitro studies, we demonstrate that this interaction could be a switch to replace p53 with TFIIE on TFIIH in transcription.
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(as it appears on PubMed at http://www.pubmed.gov), where 18354501 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18354501}}
==About this Structure==
==About this Structure==
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2RNQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNQ OCA].
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2RNQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNQ OCA].
==Reference==
==Reference==
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[[Category: Human tfiih p62]]
[[Category: Human tfiih p62]]
[[Category: Ph domain]]
[[Category: Ph domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:29:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:14:43 2008''

Revision as of 11:14, 27 July 2008

Image:2rnq.png

Template:STRUCTURE 2rnq

Solution structure of the C-terminal acidic domain of TFIIE alpha

Template:ABSTRACT PUBMED 18354501

About this Structure

2RNQ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH., Okuda M, Tanaka A, Satoh M, Mizuta S, Takazawa M, Ohkuma Y, Nishimura Y, EMBO J. 2008 Mar 20;. PMID:18354501

Page seeded by OCA on Sun Jul 27 14:14:43 2008

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