2h34

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{{STRUCTURE_2h34| PDB=2h34 | SCENE= }}
{{STRUCTURE_2h34| PDB=2h34 | SCENE= }}
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'''Apoenzyme crystal structure of the tuberculosis serine/threonine kinase, PknE'''
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===Apoenzyme crystal structure of the tuberculosis serine/threonine kinase, PknE===
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==Overview==
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The "eukaryotic-like" receptor Ser/Thr protein kinases (STPKs) are candidates for the sensors that mediate environmental adaptations of Mycobacterium tuberculosis (Mtb). To define the mechanisms of regulation and substrate recognition, we determined the crystal structure of the ligand-free, activated kinase domain (KD) of the Mtb STPK, PknE. Remarkably, the PknE KD formed a dimer similar to that first observed in the structure of the ATPgammaS complex of the Mtb paralog, PknB. This structural similarity, which occurs despite little sequence conservation between the PknB and PknE dimer interfaces, supports the idea that dimerization regulates the Mtb receptor STPKs. Insertion of the DFG motif into the ATP-binding site and other conformational differences compared the ATPgammaS:PknB complex suggest that apo-PknE is not pre-organized to bind nucleotides. This structure may represent an inactive conformation stabilized by dimerization or, alternatively, an active conformation that reveals shifts that mediate nucleotide exchange and order substrate binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 16762364 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16762364}}
==About this Structure==
==About this Structure==
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[[Category: Apoenzyme]]
[[Category: Apoenzyme]]
[[Category: Serine/threonine protein kinase]]
[[Category: Serine/threonine protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:48:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:15:05 2008''

Revision as of 11:15, 27 July 2008

Image:2h34.png

Template:STRUCTURE 2h34

Apoenzyme crystal structure of the tuberculosis serine/threonine kinase, PknE

Template:ABSTRACT PUBMED 16762364

About this Structure

2H34 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

A conserved dimer and global conformational changes in the structure of apo-PknE Ser/Thr protein kinase from Mycobacterium tuberculosis., Gay LM, Ng HL, Alber T, J Mol Biol. 2006 Jul 7;360(2):409-20. Epub 2006 May 19. PMID:16762364

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