1y6e

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{{STRUCTURE_1y6e| PDB=1y6e | SCENE= }}
{{STRUCTURE_1y6e| PDB=1y6e | SCENE= }}
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'''Orthorhombic glutathione S-transferase of Schistosoma japonicum'''
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===Orthorhombic glutathione S-transferase of Schistosoma japonicum===
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==Overview==
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The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.
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The line below this paragraph, {{ABSTRACT_PUBMED_16511012}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16511012 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16511012}}
==About this Structure==
==About this Structure==
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[[Category: Thiebach, L.]]
[[Category: Thiebach, L.]]
[[Category: Dimer]]
[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:16:03 2008''

Revision as of 11:16, 27 July 2008

Image:1y6e.png

Template:STRUCTURE 1y6e

Orthorhombic glutathione S-transferase of Schistosoma japonicum

Template:ABSTRACT PUBMED 16511012

About this Structure

1Y6E is a Single protein structure of sequence from Schistosoma japonicum. Full crystallographic information is available from OCA.

Reference

X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site., Rufer AC, Thiebach L, Baer K, Klein HW, Hennig M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):263-5. Epub 2005 Feb 24. PMID:16511012

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