1p4o

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{{STRUCTURE_1p4o| PDB=1p4o | SCENE= }}
{{STRUCTURE_1p4o| PDB=1p4o | SCENE= }}
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'''Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution.'''
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===Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution.===
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==Overview==
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The crystal structure of the wild-type unactivated kinase domain (IGFRK-0P) of insulin-like growth factor-1 receptor has been reported previously at 2.7 A resolution [Munshi et al. (2002), J. Biol. Chem. 277, 38797-38802]. In order to obtain a high-resolution structure, a number of variants of IGFRK-0P were prepared and screened for crystallization. A double mutant with E1067A and E1069A substitutions within the kinase-insert region resulted in crystals that diffracted to 1.5 A resolution. Overall, the structure of the mutant IGFRK-0P is similar to that of the wild-type IGFRK-0P structure, with the exception of the previously disordered kinase-insert region in the wild type having become fixed. In addition, amino-acid residues 947-952 at the N-terminus are well defined in the mutant structure. The monomeric protein structure is folded into two lobes connected by a hinge region, with the catalytic center situated at the interface of the two lobes. Two molecules of IGFRK-0P in the asymmetric unit are associated as a dimer and two different types of dimers with their ATP-binding clefts either facing towards or away from each other are observed. The current refined model consists of a dimer and 635 water molecules.
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{{ABSTRACT_PUBMED_14501110}}
==Disease==
==Disease==
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[[Category: Igf-1r]]
[[Category: Igf-1r]]
[[Category: Kinase domain]]
[[Category: Kinase domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:40:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:18:03 2008''

Revision as of 11:18, 27 July 2008

Image:1p4o.png

Template:STRUCTURE 1p4o

Contents

Structure of Apo unactivated IGF-1R KInase domain at 1.5A resolution.

Template:ABSTRACT PUBMED 14501110

Disease

Known disease associated with this structure: Intrauterine and postnatal growth retardation OMIM:[147370]

About this Structure

1P4O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution., Munshi S, Hall DL, Kornienko M, Darke PL, Kuo LC, Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1725-30. Epub 2003, Sep 19. PMID:14501110

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