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2pvc

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{{STRUCTURE_2pvc| PDB=2pvc | SCENE= }}
{{STRUCTURE_2pvc| PDB=2pvc | SCENE= }}
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'''DNMT3L recognizes unmethylated histone H3 lysine 4'''
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===DNMT3L recognizes unmethylated histone H3 lysine 4===
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==Overview==
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Mammals use DNA methylation for the heritable silencing of retrotransposons and imprinted genes and for the inactivation of the X chromosome in females. The establishment of patterns of DNA methylation during gametogenesis depends in part on DNMT3L, an enzymatically inactive regulatory factor that is related in sequence to the DNA methyltransferases DNMT3A and DNMT3B. The main proteins that interact in vivo with the product of an epitope-tagged allele of the endogenous Dnmt3L gene were identified by mass spectrometry as DNMT3A2, DNMT3B and the four core histones. Peptide interaction assays showed that DNMT3L specifically interacts with the extreme amino terminus of histone H3; this interaction was strongly inhibited by methylation at lysine 4 of histone H3 but was insensitive to modifications at other positions. Crystallographic studies of human DNMT3L showed that the protein has a carboxy-terminal methyltransferase-like domain and an N-terminal cysteine-rich domain. Cocrystallization of DNMT3L with the tail of histone H3 revealed that the tail bound to the cysteine-rich domain of DNMT3L, and substitution of key residues in the binding site eliminated the H3 tail-DNMT3L interaction. These data indicate that DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2.
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{{ABSTRACT_PUBMED_17687327}}
==About this Structure==
==About this Structure==
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[[Category: Transferase regulator]]
[[Category: Transferase regulator]]
[[Category: Unmethylated h3k4]]
[[Category: Unmethylated h3k4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:23:56 2008''

Revision as of 11:23, 27 July 2008

Image:2pvc.png

Template:STRUCTURE 2pvc

DNMT3L recognizes unmethylated histone H3 lysine 4

Template:ABSTRACT PUBMED 17687327

About this Structure

2PVC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA., Ooi SK, Qiu C, Bernstein E, Li K, Jia D, Yang Z, Erdjument-Bromage H, Tempst P, Lin SP, Allis CD, Cheng X, Bestor TH, Nature. 2007 Aug 9;448(7154):714-7. PMID:17687327

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