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1xgl

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{{STRUCTURE_1xgl| PDB=1xgl | SCENE= }}
{{STRUCTURE_1xgl| PDB=1xgl | SCENE= }}
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'''HUMAN INSULIN DISULFIDE ISOMER, NMR, 10 STRUCTURES'''
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===HUMAN INSULIN DISULFIDE ISOMER, NMR, 10 STRUCTURES===
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==Overview==
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We have determined the structure of a metastable disulphide isomer of human insulin. Although not observed for proinsulin folding or insulin-chain recombination, the isomer retains ordered secondary structure and a compact hydrophobic core. Comparison with native insulin reveals a global rearrangement in the orientation of A- and B-chains. One face of the protein's surface is nevertheless in common between native and non-native structures. This face contains receptor-binding determinants, rationalizing the partial biological activity of the isomer. Structures of native and non-native disulphide isomers also define alternative three-dimensional templates. Threading of insulin-like sequences provide an experimental realization of the inverse protein-folding problem.
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(as it appears on PubMed at http://www.pubmed.gov), where 7749917 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7749917}}
==About this Structure==
==About this Structure==
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1XGL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XGL OCA].
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1XGL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XGL OCA].
==Reference==
==Reference==
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[[Category: Glucose metabolism]]
[[Category: Glucose metabolism]]
[[Category: Hormone]]
[[Category: Hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:00:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:26:10 2008''

Revision as of 11:26, 27 July 2008

Image:1xgl.png

Template:STRUCTURE 1xgl

HUMAN INSULIN DISULFIDE ISOMER, NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 7749917

About this Structure

1XGL is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of a protein in a kinetic trap., Hua QX, Gozani SN, Chance RE, Hoffmann JA, Frank BH, Weiss MA, Nat Struct Biol. 1995 Feb;2(2):129-38. PMID:7749917

Page seeded by OCA on Sun Jul 27 14:26:10 2008

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