1qjk

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{{STRUCTURE_1qjk| PDB=1qjk | SCENE= }}
{{STRUCTURE_1qjk| PDB=1qjk | SCENE= }}
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'''METALLOTHIONEIN MTA FROM SEA URCHIN (ALPHA DOMAIN)'''
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===METALLOTHIONEIN MTA FROM SEA URCHIN (ALPHA DOMAIN)===
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==Overview==
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The three-dimensional structure of [(113)Cd7]-metallothionein-A (MTA) of the sea urchin Strongylocentrotus purpuratus was determined by homonuclear(1)H NMR experiments and heteronuclear [(1)H, (113)Cd]-correlation spectroscopy. MTA is composed of two globular domains, an N-terminal four-metal domain of the amino acid residues 1 to 36 and a Cd4Cys11cluster, and a C-terminal three-metal domain including the amino acid residues 37 to 65 and a Cd3Cys9cluster. The structure resembles the known mammalian and crustacean metallothioneins, but has a significantly different connectivity pattern of the Cys-metal co-ordination bonds and concomitantly contains novel local folds of some polypeptide backbone segments. These differences can be related to variations of the Cys sequence positions and thus emphasize the special role of the cysteine residues in defining the structure of metallothioneins, both on the level of the domain architecture and the topology of the metal-thiolate clusters.
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{{ABSTRACT_PUBMED_10438629}}
==About this Structure==
==About this Structure==
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1QJK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJK OCA].
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1QJK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Strongylocentrotus_purpuratus Strongylocentrotus purpuratus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJK OCA].
==Reference==
==Reference==
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[[Category: Metallothionein]]
[[Category: Metallothionein]]
[[Category: Radical scavenger]]
[[Category: Radical scavenger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:26:32 2008''

Revision as of 11:26, 27 July 2008

Image:1qjk.png

Template:STRUCTURE 1qjk

METALLOTHIONEIN MTA FROM SEA URCHIN (ALPHA DOMAIN)

Template:ABSTRACT PUBMED 10438629

About this Structure

1QJK is a Single protein structure of sequence from Strongylocentrotus purpuratus. Full experimental information is available from OCA.

Reference

NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA., Riek R, Precheur B, Wang Y, Mackay EA, Wider G, Guntert P, Liu A, Kagi JH, Wuthrich K, J Mol Biol. 1999 Aug 13;291(2):417-28. PMID:10438629

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