2q2t

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{{STRUCTURE_2q2t| PDB=2q2t | SCENE= }}
{{STRUCTURE_2q2t| PDB=2q2t | SCENE= }}
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'''Structure of Chlorella virus DNA ligase-adenylate bound to a 5' phosphorylated nick'''
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===Structure of Chlorella virus DNA ligase-adenylate bound to a 5' phosphorylated nick===
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==Overview==
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Chlorella virus DNA ligase, the smallest eukaryotic ligase known, has pluripotent biological activity and an intrinsic nick-sensing function, despite having none of the accessory domains found in cellular ligases. A 2.3-A crystal structure of the Chlorella virus ligase-AMP intermediate bound to duplex DNA containing a 3'-OH-5'-PO4 nick reveals a new mode of DNA envelopment, in which a short surface loop emanating from the OB domain forms a beta-hairpin 'latch' that inserts into the DNA major groove flanking the nick. A network of interactions with the 3'-OH and 5'-PO4 termini in the active site illuminates the DNA adenylylation mechanism and the crucial roles of AMP in nick sensing and catalysis. Addition of a divalent cation triggered nick sealing in crystallo, establishing that the nick complex is a bona fide intermediate in the DNA repair pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 17618295 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17618295}}
==About this Structure==
==About this Structure==
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[[Category: Lysine adenylate]]
[[Category: Lysine adenylate]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:13:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:27:37 2008''

Revision as of 11:27, 27 July 2008

Image:2q2t.png

Template:STRUCTURE 2q2t

Structure of Chlorella virus DNA ligase-adenylate bound to a 5' phosphorylated nick

Template:ABSTRACT PUBMED 17618295

About this Structure

2Q2T is a Single protein structure of sequence from Paramecium bursaria chlorella virus 1. Full crystallographic information is available from OCA.

Reference

Structural basis for nick recognition by a minimal pluripotent DNA ligase., Nair PA, Nandakumar J, Smith P, Odell M, Lima CD, Shuman S, Nat Struct Mol Biol. 2007 Aug;14(8):770-8. Epub 2007 Jul 8. PMID:17618295

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