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1jxc

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[[Image:1jxc.gif|left|200px]]
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{{STRUCTURE_1jxc| PDB=1jxc | SCENE= }}
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'''Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor'''
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===Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor===
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==Overview==
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The three-dimensional structure of the precursor form of the Arabidopsis thaliana trypsin inhibitor (ATT(p), GenBank entry Z46816), a 68-residue (approximately 7.5 kDa) rapeseed class proteinase inhibitor, has been determined in solution at pH 5.0 and 25 degrees C by multinuclear magnetic resonance spectroscopy. The protein contains one alpha-helix and two strands of antiparallel beta-sheet, with a type IV beta-turn connecting the two strands. The alpha-helix and the inhibitory loop are connected to the beta-sheet through three disulfide bridges; a fourth disulfide bridge connects the N- and C-termini. The overall structural topology of ATT(p) is similar to those of the sweet tasting protein brazzein (rmsd of 3.0 A) and the antifungal protein Rs-Afp1 [a knottin protein from radish (Raphanus sativus), rmsd of 2.7 A]. The precursor segment in ATT(p) is disordered, as visualized by the final 20-conformer ensemble and as confirmed by (15)N heteronuclear NOE analysis. The overall fold of ATT(p) is distinct from those of other classes of serine proteinase inhibitors except in the inhibitor loop; therefore, it represents a new inhibitor fold.
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(as it appears on PubMed at http://www.pubmed.gov), where 12369816 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12369816}}
==About this Structure==
==About this Structure==
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1JXC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXC OCA].
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1JXC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXC OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Trypsin inhibitor]]
[[Category: Trypsin inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:02:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:30:53 2008''

Revision as of 11:30, 27 July 2008

Image:1jxc.png

Template:STRUCTURE 1jxc

Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor

Template:ABSTRACT PUBMED 12369816

About this Structure

1JXC is a Single protein structure of sequence from Arabidopsis thaliana. Full experimental information is available from OCA.

Reference

NMR solution structure of ATTp, an Arabidopsis thaliana trypsin inhibitor., Zhao Q, Chae YK, Markley JL, Biochemistry. 2002 Oct 15;41(41):12284-96. PMID:12369816

Page seeded by OCA on Sun Jul 27 14:30:53 2008

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