2r1b

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{{STRUCTURE_2r1b| PDB=2r1b | SCENE= }}
{{STRUCTURE_2r1b| PDB=2r1b | SCENE= }}
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'''Crystal Structure of rat neurexin 1beta with a splice insert at SS#4'''
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===Crystal Structure of rat neurexin 1beta with a splice insert at SS#4===
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==Overview==
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Neurexins and neuroligins play an essential role in synapse function, and their alterations are linked to autistic spectrum disorder. Interactions between neurexins and neuroligins regulate inhibitory and excitatory synaptogenesis in vitro through a "splice-insert signaling code." In particular, neurexin 1beta carrying an alternative splice insert at site SS#4 interacts with neuroligin 2 (found predominantly at inhibitory synapses) but much less so with other neuroligins (those carrying an insert at site B and prevalent at excitatory synapses). The structure of neurexin 1beta+SS#4 reveals dramatic rearrangements to the "hypervariable surface," the binding site for neuroligins. The splice insert protrudes as a long helix into space, triggers conversion of loop beta10-beta11 into a helix rearranging the binding site for neuroligins, and rearranges the Ca(2+)-binding site required for ligand binding, increasing its affinity. Our structures reveal the mechanism by which neurexin 1beta isoforms acquire neuroligin splice isoform selectivity.
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(as it appears on PubMed at http://www.pubmed.gov), where 18334217 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18334217}}
==About this Structure==
==About this Structure==
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[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Splicing]]
[[Category: Splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:04:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:34:44 2008''

Revision as of 11:34, 27 July 2008

Image:2r1b.png

Template:STRUCTURE 2r1b

Crystal Structure of rat neurexin 1beta with a splice insert at SS#4

Template:ABSTRACT PUBMED 18334217

About this Structure

2R1B is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Regulation of Neurexin 1beta Tertiary Structure and Ligand Binding through Alternative Splicing., Shen KC, Kuczynska DA, Wu IJ, Murray BH, Sheckler LR, Rudenko G, Structure. 2008 Mar;16(3):422-31. PMID:18334217

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