1rzt

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{{STRUCTURE_1rzt| PDB=1rzt | SCENE= }}
{{STRUCTURE_1rzt| PDB=1rzt | SCENE= }}
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'''Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule'''
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===Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule===
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==Overview==
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Human DNA polymerase lambda (Pol lambda) is a family X member with low frameshift fidelity that has been suggested to perform gap-filling DNA synthesis during base excision repair and during repair of broken ends with limited homology. Here, we present a 2.1 A crystal structure of the catalytic core of Pol lambda in complex with DNA containing a two nucleotide gap. Pol lambda makes limited contacts with the template strand at the polymerase active site, and superimposition with Pol beta in a ternary complex suggests a shift in the position of the DNA at the active site that is reminiscent of a deletion intermediate. Surprisingly, Pol lambda can adopt a closed conformation, even in the absence of dNTP binding. These observations have implications for the catalytic mechanism and putative DNA repair functions of Pol lambda.
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(as it appears on PubMed at http://www.pubmed.gov), where 14992725 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14992725}}
==About this Structure==
==About this Structure==
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[[Category: Pedersen, L C.]]
[[Category: Pedersen, L C.]]
[[Category: Dna polymerase lambda]]
[[Category: Dna polymerase lambda]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:07:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:35:44 2008''

Revision as of 11:35, 27 July 2008

Image:1rzt.png

Template:STRUCTURE 1rzt

Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule

Template:ABSTRACT PUBMED 14992725

About this Structure

1RZT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology., Garcia-Diaz M, Bebenek K, Krahn JM, Blanco L, Kunkel TA, Pedersen LC, Mol Cell. 2004 Feb 27;13(4):561-72. PMID:14992725

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