1prm

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{{STRUCTURE_1prm| PDB=1prm | SCENE= }}
{{STRUCTURE_1prm| PDB=1prm | SCENE= }}
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'''TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS'''
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===TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS===
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==Overview==
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Solution structures of two Src homology 3 (SH3) domain-ligand complexes have been determined by nuclear magnetic resonance. Each complex consists of the SH3 domain and a nine-residue proline-rich peptide selected from a large library of ligands prepared by combinatorial synthesis. The bound ligands adopt a left-handed polyproline type II (PPII) helix, although the amino to carboxyl directionalities of their helices are opposite. The peptide orientation is determined by a salt bridge formed by the terminal arginine residues of the ligands and the conserved aspartate-99 of the SH3 domain. Residues at positions 3, 4, 6, and 7 of both peptides also intercalate into the ligand-binding site; however, the respective proline and nonproline residues show exchanged binding positions in the two complexes. These structural results led to a model for the interactions of SH3 domains with proline-rich peptides that can be used to predict critical residues in complexes of unknown structure. The model was used to identify correctly both the binding orientation and the contact and noncontact residues of a peptide derived from the nucleotide exchange factor Sos in association with the amino-terminal SH3 domain of the adaptor protein Grb2.
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(as it appears on PubMed at http://www.pubmed.gov), where 7526465 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7526465}}
==About this Structure==
==About this Structure==
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1PRM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRM OCA].
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1PRM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRM OCA].
==Reference==
==Reference==
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[[Category: Simon, J A.]]
[[Category: Simon, J A.]]
[[Category: Yu, H.]]
[[Category: Yu, H.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:24:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:36:17 2008''

Revision as of 11:36, 27 July 2008

Image:1prm.png

Template:STRUCTURE 1prm

TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS

Template:ABSTRACT PUBMED 7526465

About this Structure

1PRM is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions., Feng S, Chen JK, Yu H, Simon JA, Schreiber SL, Science. 1994 Nov 18;266(5188):1241-7. PMID:7526465

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