2a6q

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[[Image:2a6q.gif|left|200px]]
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{{STRUCTURE_2a6q| PDB=2a6q | SCENE= }}
{{STRUCTURE_2a6q| PDB=2a6q | SCENE= }}
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'''Crystal structure of YefM-YoeB complex'''
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===Crystal structure of YefM-YoeB complex===
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==Overview==
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The eubacterial chromosome encodes various addiction modules that control global levels of translation through RNA degradation. Crystal structures of the Escherichia coli YefM2 (antitoxin)-YoeB (toxin) complex and the free YoeB toxin have been determined. The structure of the heterotrimeric complex reveals an asymmetric disorder-to-order recognition strategy, in which one C terminus of the YefM homodimer exclusively interacts with an atypical microbial ribonuclease (RNase) fold of YoeB. Comparison with the YefM-free YoeB structure indicates a conformational rearrangement of the RNase catalytic site of YoeB, induced by interaction with YefM. Complementary biochemical experiments demonstrate that the YoeB toxin has an in vitro RNase activity that preferentially cleaves at the 3' end of purine ribonucleotides.
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(as it appears on PubMed at http://www.pubmed.gov), where 16109374 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16109374}}
==About this Structure==
==About this Structure==
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[[Category: Yefm]]
[[Category: Yefm]]
[[Category: Yoeb]]
[[Category: Yoeb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:40:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:39:28 2008''

Revision as of 11:39, 27 July 2008

Image:2a6q.png

Template:STRUCTURE 2a6q

Crystal structure of YefM-YoeB complex

Template:ABSTRACT PUBMED 16109374

About this Structure

2A6Q is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin., Kamada K, Hanaoka F, Mol Cell. 2005 Aug 19;19(4):497-509. PMID:16109374

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