2z6h

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{{STRUCTURE_2z6h| PDB=2z6h | SCENE= }}
{{STRUCTURE_2z6h| PDB=2z6h | SCENE= }}
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'''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain'''
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===Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain===
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==Overview==
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beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.
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(as it appears on PubMed at http://www.pubmed.gov), where 18334222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18334222}}
==About this Structure==
==About this Structure==
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[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
[[Category: Wnt signaling pathway]]
[[Category: Wnt signaling pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:43:32 2008''

Revision as of 11:43, 27 July 2008

Image:2z6h.png

Template:STRUCTURE 2z6h

Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain

Template:ABSTRACT PUBMED 18334222

About this Structure

2Z6H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222

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