1ze2

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{{STRUCTURE_1ze2| PDB=1ze2 | SCENE= }}
{{STRUCTURE_1ze2| PDB=1ze2 | SCENE= }}
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'''Conformational change of pseudouridine 55 synthase upon its association with RNA substrate'''
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===Conformational change of pseudouridine 55 synthase upon its association with RNA substrate===
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==Overview==
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Pseudouridine 55 synthase (Psi55S) catalyzes isomerization of uridine (U) to pseudouridine (Psi) at position 55 in transfer RNA. The crystal structures of Thermotoga maritima Psi55S, and its complex with RNA, have been determined at 2.9 and 3.0 A resolutions, respectively. Structural comparisons with other families of pseudouridine synthases (PsiS) indicate that Psi55S may acquire its ability to recognize a stem-loop RNA substrate by two insertions of polypeptides into the PsiS core. The structure of apo-Psi55S reveals that these two insertions interact with each other. However, association with RNA substrate induces substantial conformational change in one of the insertions, resulting in disruption of interaction between insertions and association of both insertions with the RNA substrate. Specific interactions between two insertions, as well as between the insertions and the RNA substrate, account for the molecular basis of the conformational change.
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(as it appears on PubMed at http://www.pubmed.gov), where 14990747 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14990747}}
==About this Structure==
==About this Structure==
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[[Category: Phannachet, K.]]
[[Category: Phannachet, K.]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:30:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:43:51 2008''

Revision as of 11:43, 27 July 2008

Image:1ze2.png

Template:STRUCTURE 1ze2

Conformational change of pseudouridine 55 synthase upon its association with RNA substrate

Template:ABSTRACT PUBMED 14990747

About this Structure

1ZE2 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Conformational change of pseudouridine 55 synthase upon its association with RNA substrate., Phannachet K, Huang RH, Nucleic Acids Res. 2004 Feb 27;32(4):1422-9. Print 2004. PMID:14990747

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