2nyk

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{{STRUCTURE_2nyk| PDB=2nyk | SCENE= }}
{{STRUCTURE_2nyk| PDB=2nyk | SCENE= }}
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'''Crystal structure of m157 from mouse cytomegalovirus'''
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===Crystal structure of m157 from mouse cytomegalovirus===
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==Overview==
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Natural killer (NK) cells express activating and inhibitory receptors that, in concert, survey cells for proper expression of cell surface major histocompatibility complex (MHC) class I molecules. The mouse cytomegalovirus encodes an MHC-like protein, m157, which is the only known viral antigen to date capable of engaging both activating (Ly49H) and inhibitory (Ly49I) NK cell receptors. We have determined the 3D structure of m157 and studied its biochemical and cellular interactions with the Ly49H and Ly49I receptors. m157 has a characteristic MHC-fold, yet possesses several unique structural features not found in other MHC class I-like molecules. m157 does not bind peptides or other small ligands, nor does it associate with beta(2)-microglobulin. Instead, m157 engages in extensive intra- and intermolecular interactions within and between its domains to generate a compact minimal MHC-like molecule. m157's binding affinity for Ly49I (K(d) approximately 0.2 microM) is significantly higher than that of classical inhibitory Ly49-MHC interactions. Analysis of viral escape mutations on m157 that render it resistant to NK killing reveals that it is likely to be recognized by Ly49H in a binding mode that differs from Ly49/MHC-I. In addition, Ly49H+ NK cells can efficiently lyse RMA cells expressing m157, despite the presence of native MHC class I. Collectively, our results show that m157 represents a structurally divergent form of MHC class I-like proteins that directly engage Ly49 receptors with appreciable affinity in a noncanonical fashion.
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{{ABSTRACT_PUBMED_17537914}}
==About this Structure==
==About this Structure==
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[[Category: Nk cell]]
[[Category: Nk cell]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:46:36 2008''

Revision as of 11:46, 27 July 2008

Image:2nyk.png

Template:STRUCTURE 2nyk

Crystal structure of m157 from mouse cytomegalovirus

Template:ABSTRACT PUBMED 17537914

About this Structure

2NYK is a Single protein structure of sequence from Murid herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors., Adams EJ, Juo ZS, Venook RT, Boulanger MJ, Arase H, Lanier LL, Garcia KC, Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10128-33. Epub 2007 May 30. PMID:17537914

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