2oyv

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[[Image:2oyv.jpg|left|200px]]
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{{Seed}}
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[[Image:2oyv.png|left|200px]]
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{{STRUCTURE_2oyv| PDB=2oyv | SCENE= }}
{{STRUCTURE_2oyv| PDB=2oyv | SCENE= }}
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'''Neurotensin in DPC micelles'''
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===Neurotensin in DPC micelles===
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==Overview==
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Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
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(as it appears on PubMed at http://www.pubmed.gov), where 17441729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17441729}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYV OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYV OCA].
==Reference==
==Reference==
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[[Category: Monti, J P.]]
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[[Category: Type i turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:57:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:46:59 2008''

Revision as of 11:47, 27 July 2008

Image:2oyv.png

Template:STRUCTURE 2oyv

Neurotensin in DPC micelles

Template:ABSTRACT PUBMED 17441729

About this Structure

Full experimental information is available from OCA.

Reference

NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition., Coutant J, Curmi PA, Toma F, Monti JP, Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:17441729

Page seeded by OCA on Sun Jul 27 14:46:59 2008

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