1zyi

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[[Image:1zyi.gif|left|200px]]
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{{STRUCTURE_1zyi| PDB=1zyi | SCENE= }}
{{STRUCTURE_1zyi| PDB=1zyi | SCENE= }}
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'''Solution structure of ICLN, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing'''
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===Solution structure of ICLN, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing===
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==Overview==
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ICln is a multifunctional protein involved in regulatory mechanisms as different as membrane ion transport and RNA splicing. The protein is water-soluble, and during regulatory volume decrease after cell swelling, it is able to migrate from the cytosol to the cell membrane. Purified, water-soluble ICln is able to insert into lipid bilayers to form ion channels. Here, we show that ICln159, a truncated ICln mutant, which is also able to form ion channels in lipid bilayers, belongs to the pleckstrin homology (PH) domain superfold family of proteins. The ICln PH domain shows unusual properties as it lacks the electrostatic surface polarization seen in classical PH domains. However, similar to many classical PH domain-containing proteins, ICln interacts with protein kinase C, and in addition, interacts with cAMP-dependent protein kinase and cGMP-dependent protein kinase type II but not cGMP-dependent protein kinase type Ibeta. A major phosphorylation site for all three kinases is Ser-45 within the ICln PH domain. Furthermore, ICln159 interacts with LSm4, a protein involved in splicing and mRNA degradation, suggesting that the ICln159 PH domain may serve as a protein-protein interaction platform.
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The line below this paragraph, {{ABSTRACT_PUBMED_15905169}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15905169 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15905169}}
==About this Structure==
==About this Structure==
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1ZYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYI OCA].
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1ZYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZYI OCA].
==Reference==
==Reference==
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[[Category: Ph domain]]
[[Category: Ph domain]]
[[Category: Rna splicing]]
[[Category: Rna splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:14:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:50:06 2008''

Revision as of 11:50, 27 July 2008

Image:1zyi.png

Template:STRUCTURE 1zyi

Solution structure of ICLN, a multifunctional protein involved in regulatory mechanisms as different as cell volume regulation and rna splicing

Template:ABSTRACT PUBMED 15905169

About this Structure

1ZYI is a Single protein structure of sequence from Canis lupus familiaris. Full experimental information is available from OCA.

Reference

ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4., Furst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S, Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C, Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R, Paulmichl M, J Biol Chem. 2005 Sep 2;280(35):31276-82. Epub 2005 May 19. PMID:15905169

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