1k1s
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(New page: 200px<br /><applet load="1k1s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k1s, resolution 2.80Å" /> '''Crystal Structure of...)
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Revision as of 16:39, 20 November 2007
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Crystal Structure of DinB from Sulfolobus solfataricus
Overview
A new group of error-prone DNA polymerases overcomes the blockage posed to, normal DNA replication by damaged template bases, suggesting an active, site with a loose, flexible pocket that accommodates aberrant DNA, structures. We have determined a 2.8 A resolution crystal structure of the, Sulfolobus solfataricus Dbh protein, a DNA translesion polymerase closely, related to Escherichia coli DNA polymerase IV and human polymerase kappa., A high error rate is observed for the Dbh polymerase in a range of, 10(-2)-10(-3) for all 12 base substitution mispairs. The crystal structure, of Dbh reveals an overall architecture resembling other DNA polymerases, but has unique features that are likely to contribute to error-prone, synthesis, including -1 frameshifting mutations.
About this Structure
1K1S is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus., Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T, Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:11685247
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