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1qsc

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[[Image:1qsc.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1qsc| PDB=1qsc | SCENE= }}
{{STRUCTURE_1qsc| PDB=1qsc | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF2 IN A COMPLEX WITH A PEPTIDE FROM THE CD40 RECEPTOR'''
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===CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF2 IN A COMPLEX WITH A PEPTIDE FROM THE CD40 RECEPTOR===
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==Overview==
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Tumor necrosis factor receptor superfamily members convey signals that promote diverse cellular responses. Receptor trimerization by extracellular ligands initiates signaling by recruiting members of the tumor necrosis factor receptor-associated factor (TRAF) family of adapter proteins to the receptor cytoplasmic domains. We report the 2.4-A crystal structure of a 22-kDa, receptor-binding fragment of TRAF2 complexed with a functionally defined peptide from the cytoplasmic domain of the CD40 receptor. TRAF2 forms a mushroom-shaped trimer consisting of a coiled coil and a unique beta-sandwich domain. Both domains mediate trimerization. The CD40 peptide binds in an extended conformation with every side chain in contact with a complementary groove on the rim of each TRAF monomer. The spacing between the CD40 binding sites on TRAF2 supports an elegant signaling mechanism in which trimeric, extracellular ligands preorganize the receptors to simultaneously recognize three sites on the TRAF trimer.
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(as it appears on PubMed at http://www.pubmed.gov), where 10411888 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10411888}}
==About this Structure==
==About this Structure==
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[[Category: Tnf signaling]]
[[Category: Tnf signaling]]
[[Category: Traf]]
[[Category: Traf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:38:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:58:18 2008''

Revision as of 11:58, 27 July 2008

Image:1qsc.png

Template:STRUCTURE 1qsc

CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF2 IN A COMPLEX WITH A PEPTIDE FROM THE CD40 RECEPTOR

Template:ABSTRACT PUBMED 10411888

About this Structure

1QSC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of CD40 recognition and signaling by human TRAF2., McWhirter SM, Pullen SS, Holton JM, Crute JJ, Kehry MR, Alber T, Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8408-13. PMID:10411888

Page seeded by OCA on Sun Jul 27 14:58:18 2008

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