2e6w

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{{STRUCTURE_2e6w| PDB=2e6w | SCENE= }}
{{STRUCTURE_2e6w| PDB=2e6w | SCENE= }}
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'''Solution structure and calcium binding properties of EF-hands 3 and 4 of calsenilin'''
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===Solution structure and calcium binding properties of EF-hands 3 and 4 of calsenilin===
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==Overview==
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Calsenilin is a member of the recoverin branch of the EF-hand superfamily that is reported to interact with presenilins, regulate prodynorphin gene expression, modulate voltage-gated Kv4 potassium channel function, and bind to neurotoxins. Calsenilin is a Ca+2-binding protein and plays an important role in calcium signaling. Despite its importance in numerous neurological functions, the structure of this protein has not been reported. In the absence of Ca+2, the protein has limited spectral resolution that increases upon the addition of Ca+2. Here, we describe the three-dimensional solution structure of EF-hands 3 and 4 of calsenilin in the Ca+2-bound form. The Ca+2-bound structure consists of five alpha-helices and one two-stranded antiparallel beta-sheet. The long loop that connects EF hands 3 and 4 is highly disordered in solution. In addition to its structural effects, Ca+2 binding also increases the protein's propensity to dimerize. These changes in structure and oligomerization state induced upon Ca+2 binding may play important roles in molecular recognition during calcium signaling.
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(as it appears on PubMed at http://www.pubmed.gov), where 17962406 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17962406}}
==About this Structure==
==About this Structure==
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2E6W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6W OCA].
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2E6W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6W OCA].
==Reference==
==Reference==
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[[Category: Calcium-bound form]]
[[Category: Calcium-bound form]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:02:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:00:21 2008''

Revision as of 12:00, 27 July 2008

Image:2e6w.png

Template:STRUCTURE 2e6w

Solution structure and calcium binding properties of EF-hands 3 and 4 of calsenilin

Template:ABSTRACT PUBMED 17962406

About this Structure

2E6W is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin., Yu L, Sun C, Mendoza R, Wang J, Matayoshi ED, Hebert E, Pereda-Lopez A, Hajduk PJ, Olejniczak ET, Protein Sci. 2007 Nov;16(11):2502-9. PMID:17962406

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