1waf

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{{STRUCTURE_1waf| PDB=1waf | SCENE= }}
{{STRUCTURE_1waf| PDB=1waf | SCENE= }}
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'''DNA POLYMERASE FROM BACTERIOPHAGE RB69'''
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===DNA POLYMERASE FROM BACTERIOPHAGE RB69===
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==Overview==
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The 2.8 A resolution crystal structure of the bacteriophage RB69 gp43, a member of the eukaryotic pol alpha family of replicative DNA polymerases, shares some similarities with other polymerases but shows many differences. Although its palm domain has the same topology as other polymerases, except rat DNA polymerase beta, one of the three carboxylates required for nucleotidyl transfer is located on a different beta strand. The structures of the fingers and thumb domains are unrelated to all other known polymerase structures. The editing 3'-5' exonuclease domain of gp43 is homologous to that of E. coli DNA polymerase I but lies on the opposite side of the polymerase active site. An extended structure-based alignment of eukaryotic DNA polymerase sequences provides structural insights that should be applicable to most eukaryotic DNA polymerases.
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{{ABSTRACT_PUBMED_9215631}}
==About this Structure==
==About this Structure==
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[[Category: Wang, J.]]
[[Category: Wang, J.]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleotidyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:01:02 2008''

Revision as of 12:01, 27 July 2008

Image:1waf.png

Template:STRUCTURE 1waf

DNA POLYMERASE FROM BACTERIOPHAGE RB69

Template:ABSTRACT PUBMED 9215631

About this Structure

1WAF is a Single protein structure of sequence from Enterobacteria phage rb69. Full crystallographic information is available from OCA.

Reference

Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69., Wang J, Sattar AK, Wang CC, Karam JD, Konigsberg WH, Steitz TA, Cell. 1997 Jun 27;89(7):1087-99. PMID:9215631

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