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3bk7

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{{STRUCTURE_3bk7| PDB=3bk7 | SCENE= }}
{{STRUCTURE_3bk7| PDB=3bk7 | SCENE= }}
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'''Structure of the complete ABCE1/RNAase-L Inhibitor protein from Pyrococcus abysii'''
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===Structure of the complete ABCE1/RNAase-L Inhibitor protein from Pyrococcus abysii===
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==Overview==
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The ATP binding cassette enzyme ABCE1 (also known as RNase-L (ribonuclease L) inhibitor, Pixie, and HP68), one of the evolutionary most sequence-conserved enzymes, functions in translation initiation, ribosome biogenesis, and human immunodeficiency virus capsid assembly. However, its structural mechanism and biochemical role in these processes have not been revealed. We determined the crystal structure of Pyrococcus abyssi ABCE1 in complex with Mg(2+) and ADP to 2.8A resolution. ABCE1 consists of four structural domains. Two nucleotide binding domains are arranged in a head-to-tail orientation by a hinge domain, suggesting that these domains undergo the characteristic tweezers-like powerstroke of ABC enzymes. In contrast to all other known ABC enzymes, ABCE1 has a N-terminal iron-sulfur-cluster (FeS) domain. The FeS domain contains two [4Fe-4S] clusters and is structurally highly related to bacterial-type ferredoxins. However, one cluster is coordinated by an unusual CX(4)CX(3/4)C triad. Surprisingly, intimate interactions of the FeS domain with the adenine and ribose binding Y-loop on nucleotide binding domain 1 suggest a linkage between FeS domain function and ATP-induced conformational control of the ABC tandem cassette. The structure substantially expands the functional architecture of ABC enzymes and raises the possibility that ABCE1 is a chemomechanical engine linked to a redox process.
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==About this Structure==
==About this Structure==
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[[Category: Iron-sulfur cluster]]
[[Category: Iron-sulfur cluster]]
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:52:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:02:01 2008''

Revision as of 12:02, 27 July 2008

Image:3bk7.png

Template:STRUCTURE 3bk7

Structure of the complete ABCE1/RNAase-L Inhibitor protein from Pyrococcus abysii

Template:ABSTRACT PUBMED 18160405

About this Structure

3BK7 is a Single protein structure of sequence from Pyrococcus abyssi. Full crystallographic information is available from OCA.

Reference

X-ray Structure of the Complete ABC Enzyme ABCE1 from Pyrococcus abyssi., Karcher A, Schele A, Hopfner KP, J Biol Chem. 2008 Mar 21;283(12):7962-71. Epub 2007 Dec 26. PMID:18160405

Page seeded by OCA on Sun Jul 27 15:02:01 2008

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