2j0u

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[[Image:2j0u.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2j0u| PDB=2j0u | SCENE= }}
{{STRUCTURE_2j0u| PDB=2j0u | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF EIF4AIII-BARENTSZ COMPLEX AT 3.0 A RESOLUTION'''
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===THE CRYSTAL STRUCTURE OF EIF4AIII-BARENTSZ COMPLEX AT 3.0 A RESOLUTION===
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==Overview==
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The exon junction complex (EJC) plays a major role in posttranscriptional regulation of mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of the spliced mRNA. The complex is formed by the association of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. The 2.2 A resolution structure of the EJC reveals how it stably locks onto mRNA. The DEAD-box protein eIF4AIII encloses an ATP molecule and provides the binding sites for six ribonucleotides. Btz wraps around eIF4AIII and stacks against the 5' nucleotide. An intertwined network of interactions anchors Mago-Y14 and Btz at the interface between the two domains of eIF4AIII, effectively stabilizing the ATP bound state. Comparison with the structure of the eIF4AIII-Btz subcomplex that we have also determined reveals that large conformational changes are required upon EJC assembly and disassembly.
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The line below this paragraph, {{ABSTRACT_PUBMED_16923391}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16923391 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16923391}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding]]
[[Category: Rna-binding]]
[[Category: Rrna processing]]
[[Category: Rrna processing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:10:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:03:54 2008''

Revision as of 12:03, 27 July 2008

Image:2j0u.png

Template:STRUCTURE 2j0u

THE CRYSTAL STRUCTURE OF EIF4AIII-BARENTSZ COMPLEX AT 3.0 A RESOLUTION

Template:ABSTRACT PUBMED 16923391

About this Structure

2J0U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA., Bono F, Ebert J, Lorentzen E, Conti E, Cell. 2006 Aug 25;126(4):713-25. PMID:16923391

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