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2dfw

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{{STRUCTURE_2dfw| PDB=2dfw | SCENE= }}
{{STRUCTURE_2dfw| PDB=2dfw | SCENE= }}
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'''Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3'''
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===Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3===
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==Overview==
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Glutaminase of Micrococcus luteus K-3 (intact glutaminase; 48kDa) is digested to a C-terminally truncated fragment (glutaminase fragment; 42kDa) that shows higher salt tolerance than that of the intact glutaminase. The crystal structure of the glutaminase fragment was determined at 2.4A resolution using multiple-wavelength anomalous dispersion (MAD). The glutaminase fragment is composed of N-terminal and C-terminal domains, and a putative catalytic serine-lysine dyad (S64 and K67) is located in a cleft of the N-terminal domain. Mutations of the S64 or K67 residues abolished the enzyme activity. The N-terminal domain has abundant glutamic acid residues on its surface, which may explain its salt-tolerant mechanism. A diffraction analysis of the intact glutaminase crystals (a twinning fraction of 0.43) located the glutaminase fragment in the unit cell but failed to turn up clear densities for the missing C-terminal portion of the molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 16793004 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16793004}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta structure]]
[[Category: Alpha/beta structure]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:20:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:06:26 2008''

Revision as of 12:06, 27 July 2008

Image:2dfw.png

Template:STRUCTURE 2dfw

Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3

Template:ABSTRACT PUBMED 16793004

About this Structure

2DFW is a Single protein structure of sequence from Micrococcus luteus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a major fragment of the salt-tolerant glutaminase from Micrococcus luteus K-3., Yoshimune K, Shirakihara Y, Shiratori A, Wakayama M, Chantawannakul P, Moriguchi M, Biochem Biophys Res Commun. 2006 Aug 11;346(4):1118-24. Epub 2006 Jun 6. PMID:16793004

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