1yp0

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[[Image:1yp0.gif|left|200px]]
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{{Seed}}
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[[Image:1yp0.png|left|200px]]
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{{STRUCTURE_1yp0| PDB=1yp0 | SCENE= }}
{{STRUCTURE_1yp0| PDB=1yp0 | SCENE= }}
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'''Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a SHP peptide motif'''
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===Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a SHP peptide motif===
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==Overview==
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The orphan nuclear receptor steroidogenic factor 1 (SF-1) regulates the differentiation and function of endocrine glands. Although SF-1 is constitutively active in cell-based assays, it is not known whether this transcriptional activity is modulated by ligands. Here, we describe the 1.5 angstroms crystal structure of the SF-1 ligand binding domain in complex with an LXXLL motif from a coregulator protein. The structure reveals the presence of a phospholipid ligand in a surprisingly large pocket (approximately 1600 angstroms3), with the receptor adopting the canonical active conformation. The bound phospholipid is readily exchanged and modulates SF-1 interactions with coactivators. Mutations designed to reduce the size of the SF-1 pocket or to disrupt hydrogen bonds with the phospholipid abolish SF-1/coactivator interactions and significantly reduce SF-1 transcriptional activity. These findings provide evidence that SF-1 is regulated by endogenous ligands and suggest an unexpected relationship between phospholipids and endocrine development and function.
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The line below this paragraph, {{ABSTRACT_PUBMED_15721253}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15721253 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15721253}}
==About this Structure==
==About this Structure==
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[[Category: Nr5a1]]
[[Category: Nr5a1]]
[[Category: Steroidogenic factor-1]]
[[Category: Steroidogenic factor-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:36:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:07:03 2008''

Revision as of 12:07, 27 July 2008

Image:1yp0.png

Template:STRUCTURE 1yp0

Structure of the steroidogenic factor-1 ligand binding domain bound to phospholipid and a SHP peptide motif

Template:ABSTRACT PUBMED 15721253

About this Structure

1YP0 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1., Li Y, Choi M, Cavey G, Daugherty J, Suino K, Kovach A, Bingham NC, Kliewer SA, Xu HE, Mol Cell. 2005 Feb 18;17(4):491-502. PMID:15721253

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