1u7t

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[[Image:1u7t.gif|left|200px]]
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{{STRUCTURE_1u7t| PDB=1u7t | SCENE= }}
{{STRUCTURE_1u7t| PDB=1u7t | SCENE= }}
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'''Crystal Structure of ABAD/HSD10 with a Bound Inhibitor'''
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===Crystal Structure of ABAD/HSD10 with a Bound Inhibitor===
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==Overview==
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The enzyme 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), also known as amyloid beta-peptide-binding alcohol dehydrogenase (ABAD), has been implicated in the development of Alzheimer's disease. This protein, a member of the short-chain dehydrogenase/reductase family of enzymes, has been shown to bind beta-amyloid and to participate in beta-amyloid neurotoxicity. We have determined the crystal structure of human ABAD/HSD10 complexed with NAD(+) and an inhibitory small molecule. The inhibitor occupies the substrate-binding site and forms a covalent adduct with the NAD(+) cofactor. The crystal structure provides a basis for the design of potent, highly specific ABAD/HSD10 inhibitors with potential application in the treatment of Alzheimer's disease.
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The line below this paragraph, {{ABSTRACT_PUBMED_15342248}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15342248 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15342248}}
==About this Structure==
==About this Structure==
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[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:52:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:10:49 2008''

Revision as of 12:10, 27 July 2008

Image:1u7t.png

Template:STRUCTURE 1u7t

Crystal Structure of ABAD/HSD10 with a Bound Inhibitor

Template:ABSTRACT PUBMED 15342248

About this Structure

1U7T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics., Kissinger CR, Rejto PA, Pelletier LA, Thomson JA, Showalter RE, Abreo MA, Agree CS, Margosiak S, Meng JJ, Aust RM, Vanderpool D, Li B, Tempczyk-Russell A, Villafranca JE, J Mol Biol. 2004 Sep 17;342(3):943-52. PMID:15342248

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