1qhk

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[[Image:1qhk.jpg|left|200px]]
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{{Seed}}
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[[Image:1qhk.png|left|200px]]
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{{STRUCTURE_1qhk| PDB=1qhk | SCENE= }}
{{STRUCTURE_1qhk| PDB=1qhk | SCENE= }}
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'''N-TERMINAL DOMAIN OF SACCHAROMYCES CEREVISIAE RNASE HI REVEALS A FOLD WITH A RESEMBLANCE TO THE N-TERMINAL DOMAIN OF RIBOSOMAL PROTEIN L9'''
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===N-TERMINAL DOMAIN OF SACCHAROMYCES CEREVISIAE RNASE HI REVEALS A FOLD WITH A RESEMBLANCE TO THE N-TERMINAL DOMAIN OF RIBOSOMAL PROTEIN L9===
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==Overview==
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In addition to the conserved and well-defined RNase H domain, eukaryotic RNases HI possess either one or two copies of a small N-terminal domain. The solution structure of one of the N-terminal domains from Saccharomyces cerevisiae RNase HI, determined using NMR spectroscopy, is presented. The 46 residue motif comprises a three-stranded antiparallel beta-sheet and two short alpha-helices which pack onto opposite faces of the beta-sheet. Conserved residues involved in packing the alpha-helices onto the beta-sheet form the hydrophobic core of the domain. Three highly conserved and solvent exposed residues are implicated in RNA binding, W22, K38 and K39. The beta-beta-alpha-beta-alpha topology of the domain differs from the structures of known RNA binding domains such as the double-stranded RNA binding domain (dsRBD), the hnRNP K homology (KH) domain and the RNP motif. However, structural similarities exist between this domain and the N-terminal domain of ribosomal protein L9 which binds to 23 S ribosomal RNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_10448044}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10448044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10448044}}
==About this Structure==
==About this Structure==
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1QHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHK OCA].
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1QHK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHK OCA].
==Reference==
==Reference==
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[[Category: Evans, S P.]]
[[Category: Evans, S P.]]
[[Category: Ribonuclease hi n-terminal domain]]
[[Category: Ribonuclease hi n-terminal domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:16:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:10:58 2008''

Revision as of 12:10, 27 July 2008

Image:1qhk.png

Template:STRUCTURE 1qhk

N-TERMINAL DOMAIN OF SACCHAROMYCES CEREVISIAE RNASE HI REVEALS A FOLD WITH A RESEMBLANCE TO THE N-TERMINAL DOMAIN OF RIBOSOMAL PROTEIN L9

Template:ABSTRACT PUBMED 10448044

About this Structure

1QHK is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

NMR structure of the N-terminal domain of Saccharomyces cerevisiae RNase HI reveals a fold with a strong resemblance to the N-terminal domain of ribosomal protein L9., Evans SP, Bycroft M, J Mol Biol. 1999 Aug 20;291(3):661-9. PMID:10448044

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