2shp

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[[Image:2shp.gif|left|200px]]
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{{STRUCTURE_2shp| PDB=2shp | SCENE= }}
{{STRUCTURE_2shp| PDB=2shp | SCENE= }}
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'''TYROSINE PHOSPHATASE SHP-2'''
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===TYROSINE PHOSPHATASE SHP-2===
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==Overview==
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The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 angstroms resolution, shows how its catalytic activity is regulated by its two SH2 domains. In the absence of a tyrosine-phosphorylated binding partner, the N-terminal SH2 domain binds the phosphatase domain and directly blocks its active site. This interaction alters the structure of the N-SH2 domain, disrupting its phosphopeptide-binding cleft. Conversely, interaction of the N-SH2 domain with phosphopeptide disrupts its phosphatase recognition surface. Thus, the N-SH2 domain is a conformational switch; it either binds and inhibits the phosphatase, or it binds phosphoproteins and activates the enzyme. Recognition of bisphosphorylated ligands by the tandem SH2 domains is an integral element of this switch; the C-terminal SH2 domain contributes binding energy and specificity, but it does not have a direct role in activation.
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(as it appears on PubMed at http://www.pubmed.gov), where 9491886 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9491886}}
==About this Structure==
==About this Structure==
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[[Category: Sh2 protein]]
[[Category: Sh2 protein]]
[[Category: Tyrosine phosphatase]]
[[Category: Tyrosine phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:19:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:14:45 2008''

Revision as of 12:14, 27 July 2008

Image:2shp.png

Template:STRUCTURE 2shp

TYROSINE PHOSPHATASE SHP-2

Template:ABSTRACT PUBMED 9491886

About this Structure

2SHP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tyrosine phosphatase SHP-2., Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE, Cell. 1998 Feb 20;92(4):441-50. PMID:9491886

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