1s3a

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{{STRUCTURE_1s3a| PDB=1s3a | SCENE= }}
{{STRUCTURE_1s3a| PDB=1s3a | SCENE= }}
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'''NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)'''
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===NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)===
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==Overview==
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Subunit B8 from ubiquinone oxidoreductase (complex I) (CI-B8) is one of several nuclear-encoded supernumerary subunits that are not present in bacterial complex I. Its solution structure shows a thioredoxin fold with highest similarities to the human thioredoxin mutant C73S and thioredoxin 2 from Anabeana sp. Interestingly, these proteins contain active sites in the same area, where the disulfide bond of oxidized CI-B8 is located. The redox potential of this disulfide bond is -251.6 mV, comparing well to that of disulfides in other thioredoxin-like proteins. Analysis of the structure reveals a surface area that is exclusively composed of highly conserved residues and thus most likely a subunit interaction site within complex I.
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{{ABSTRACT_PUBMED_15341729}}
==About this Structure==
==About this Structure==
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1S3A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3A OCA].
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1S3A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3A OCA].
==Reference==
==Reference==
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[[Category: Ndufa2]]
[[Category: Ndufa2]]
[[Category: Nmr]]
[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:14:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:15:31 2008''

Revision as of 12:15, 27 July 2008

Image:1s3a.png

Template:STRUCTURE 1s3a

NMR Solution Structure of Subunit B8 from Human NADH-Ubiquinone Oxidoreductase Complex I (CI-B8)

Template:ABSTRACT PUBMED 15341729

About this Structure

1S3A is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The oxidized subunit B8 from human complex I adopts a thioredoxin fold., Brockmann C, Diehl A, Rehbein K, Strauss H, Schmieder P, Korn B, Kuhne R, Oschkinat H, Structure. 2004 Sep;12(9):1645-54. PMID:15341729

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