2pm7

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{{Seed}}
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{{STRUCTURE_2pm7| PDB=2pm7 | SCENE= }}
{{STRUCTURE_2pm7| PDB=2pm7 | SCENE= }}
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'''Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version'''
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===Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version===
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==Overview==
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COPII-coated vesicles export newly synthesized proteins from the endoplasmic reticulum. The COPII coat consists of the Sec23/24-Sar1 complex that selects cargo and the Sec13/31 assembly unit that can polymerize into an octahedral cage and deform the membrane into a bud. Crystallographic analysis of the assembly unit reveals a 28 nm long rod comprising a central alpha-solenoid dimer capped by two beta-propeller domains at each end. We construct a molecular model of the COPII cage by fitting Sec13/31 crystal structures into a recently determined electron microscopy density map. The vertex geometry involves four copies of the Sec31 beta-propeller that converge through their axial ends; there is no interdigitation of assembly units of the kind seen in clathrin cages. We also propose that the assembly unit has a central hinge-an arrangement of interlocked alpha-solenoids-about which it can bend to adapt to cages of variable curvature.
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(as it appears on PubMed at http://www.pubmed.gov), where 17604721 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17604721}}
==About this Structure==
==About this Structure==
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[[Category: Alpha solenoid]]
[[Category: Alpha solenoid]]
[[Category: Beta propeller]]
[[Category: Beta propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:24:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:17:48 2008''

Revision as of 12:17, 27 July 2008

Image:2pm7.png

Template:STRUCTURE 2pm7

Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version

Template:ABSTRACT PUBMED 17604721

About this Structure

2PM7 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and organization of coat proteins in the COPII cage., Fath S, Mancias JD, Bi X, Goldberg J, Cell. 2007 Jun 29;129(7):1325-36. PMID:17604721

Page seeded by OCA on Sun Jul 27 15:17:48 2008

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