1uap

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{{STRUCTURE_1uap| PDB=1uap | SCENE= }}
{{STRUCTURE_1uap| PDB=1uap | SCENE= }}
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'''NMR structure of the NTR domain from human PCOLCE1'''
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===NMR structure of the NTR domain from human PCOLCE1===
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==Overview==
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Procollagen C-proteinase enhancer (PCOLCE) proteins are extracellular matrix proteins that enhance the activities of procollagen C-proteinases by binding to the C-propeptide of procollagen I. PCOLCE proteins are built of three structural modules, consisting of two CUB domains followed by a C-terminal netrin-like (NTR) domain. While the enhancement of proteinase activity can be ascribed solely to the CUB domains, sequence homology of the NTR domain with tissue inhibitors of metalloproteinases suggest proteinase inhibitory activity for the NTR domain. Here we present the three-dimensional structure of the NTR domain of human PCOLCE1 as the first example of a structural domain with the canonical features of an NTR module. The structure rules out a binding mode to metalloproteinases similar to that of tissue inhibitors of metalloproteinases but suggests possible inhibitory function toward specific serine proteinases. Sequence conservation between 13 PCOLCE proteins from different organisms suggests a conserved binding surface for other protein partners.
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{{ABSTRACT_PUBMED_12670942}}
==About this Structure==
==About this Structure==
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1UAP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAP OCA].
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1UAP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAP OCA].
==Reference==
==Reference==
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[[Category: Trexler, M.]]
[[Category: Trexler, M.]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:18:16 2008''

Revision as of 12:18, 27 July 2008

Image:1uap.png

Template:STRUCTURE 1uap

NMR structure of the NTR domain from human PCOLCE1

Template:ABSTRACT PUBMED 12670942

About this Structure

1UAP is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding., Liepinsh E, Banyai L, Pintacuda G, Trexler M, Patthy L, Otting G, J Biol Chem. 2003 Jul 11;278(28):25982-9. Epub 2003 Apr 1. PMID:12670942

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