1okc

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[[Image:1okc.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1okc| PDB=1okc | SCENE= }}
{{STRUCTURE_1okc| PDB=1okc | SCENE= }}
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'''STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE'''
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===STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE===
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==Overview==
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ATP, the principal energy currency of the cell, fuels most biosynthetic reactions in the cytoplasm by its hydrolysis into ADP and inorganic phosphate. Because resynthesis of ATP occurs in the mitochondrial matrix, ATP is exported into the cytoplasm while ADP is imported into the matrix. The exchange is accomplished by a single protein, the ADP/ATP carrier. Here we have solved the bovine carrier structure at a resolution of 2.2 A by X-ray crystallography in complex with an inhibitor, carboxyatractyloside. Six alpha-helices form a compact transmembrane domain, which, at the surface towards the space between inner and outer mitochondrial membranes, reveals a deep depression. At its bottom, a hexapeptide carrying the signature of nucleotide carriers (RRRMMM) is located. Our structure, together with earlier biochemical results, suggests that transport substrates bind to the bottom of the cavity and that translocation results from a transient transition from a 'pit' to a 'channel' conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 14603310 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14603310}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotide translocation]]
[[Category: Nucleotide translocation]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:57:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:18:43 2008''

Revision as of 12:18, 27 July 2008

Image:1okc.png

Template:STRUCTURE 1okc

STRUCTURE OF MITOCHONDRIAL ADP/ATP CARRIER IN COMPLEX WITH CARBOXYATRACTYLOSIDE

Template:ABSTRACT PUBMED 14603310

About this Structure

1OKC is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside., Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trezeguet V, Lauquin GJ, Brandolin G, Nature. 2003 Nov 6;426(6962):39-44. PMID:14603310

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