1y9l

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[[Image:1y9l.gif|left|200px]]
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{{Seed}}
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[[Image:1y9l.png|left|200px]]
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{{STRUCTURE_1y9l| PDB=1y9l | SCENE= }}
{{STRUCTURE_1y9l| PDB=1y9l | SCENE= }}
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'''The X-ray structure of an secretion system protein'''
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===The X-ray structure of an secretion system protein===
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==Overview==
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The ability to translocate virulence proteins into host cells through a type III secretion apparatus (TTSS) is a hallmark of several Gram-negative pathogens including Shigella, Salmonella, Yersinia, Pseudomonas, and enteropathogenic Escherichia coli. In common with other types of bacterial secretion apparatus, the assembly of the TTSS complex requires the preceding formation of its integral outer membrane secretin ring component. We have determined at 1.5 A the structure of MxiM28-142, the Shigella pilot protein that is essential for the assembly and membrane association of the Shigella secretin, MxiD. This represents the first atomic structure of a secretin pilot protein from the several bacterial secretion systems containing an orthologous secretin component. A deep hydrophobic cavity is observed in the novel 'cracked barrel' structure of MxiM, providing a specific binding domain for the acyl chains of bacterial lipids, a proposal that is supported by our various lipid/MxiM complex structures. Isothermal titration analysis shows that the C-terminal domain of the secretin, MxiD525-570, hinders lipid binding to MxiM.
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The line below this paragraph, {{ABSTRACT_PUBMED_15775974}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15775974 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15775974}}
==About this Structure==
==About this Structure==
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[[Category: Cracked beta barrel]]
[[Category: Cracked beta barrel]]
[[Category: Mixed alpha/beta]]
[[Category: Mixed alpha/beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:02:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:21:50 2008''

Revision as of 12:21, 27 July 2008

Image:1y9l.png

Template:STRUCTURE 1y9l

The X-ray structure of an secretion system protein

Template:ABSTRACT PUBMED 15775974

About this Structure

1Y9L is a Single protein structure of sequence from Shigella flexneri. Full crystallographic information is available from OCA.

Reference

Structure and biochemical analysis of a secretin pilot protein., Lario PI, Pfuetzner RA, Frey EA, Creagh L, Haynes C, Maurelli AT, Strynadka NC, EMBO J. 2005 Mar 23;24(6):1111-21. Epub 2005 Mar 10. PMID:15775974

Page seeded by OCA on Sun Jul 27 15:21:50 2008

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