2pt7

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{{STRUCTURE_2pt7| PDB=2pt7 | SCENE= }}
{{STRUCTURE_2pt7| PDB=2pt7 | SCENE= }}
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'''Crystal structure of Cag VirB11 (HP0525) and an inhibitory protein (HP1451)'''
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===Crystal structure of Cag VirB11 (HP0525) and an inhibitory protein (HP1451)===
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==Overview==
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Helicobacter pylori is one of the world's most successful human pathogens causing gastric ulcers and cancers. A key virulence factor of H. pylori is the Cag pathogenicity island, which encodes a type IV secretion system. HP0525 is an essential component of the Cag system and acts as an inner membrane associated ATPase. HP0525 forms double hexameric ring structures, with the C-terminal domains (CTDs) forming a closed ring and the N-terminal domains (NTDs) forming a dynamic, open ring. Here, the crystal structure of HP0525 in complex with a fragment of HP1451, a protein of previously unknown function, is reported. The HP1451 construct consists of two domains similar to nucleic acid-binding domains. Two HP1451 molecules bind to the HP0525 NTDs on opposite sides of the hexamer, locking it in the closed form and forming a partial lid over the HP0525 chamber. From the structure, it is suggested that HP1451 acts as an inhibitory factor of HP0525 to regulate Cag-mediated secretion, a suggestion confirmed by results of in vitro ATPase assay and in vivo pull-down experiments.
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{{ABSTRACT_PUBMED_17972918}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Type iv secretion]]
[[Category: Type iv secretion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:46:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:23:21 2008''

Revision as of 12:23, 27 July 2008

Image:2pt7.png

Template:STRUCTURE 2pt7

Crystal structure of Cag VirB11 (HP0525) and an inhibitory protein (HP1451)

Template:ABSTRACT PUBMED 17972918

About this Structure

2PT7 is a Protein complex structure of sequences from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase., Hare S, Fischer W, Williams R, Terradot L, Bayliss R, Haas R, Waksman G, EMBO J. 2007 Nov 28;26(23):4926-34. Epub 2007 Nov 1. PMID:17972918

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