2b8v

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[[Image:2b8v.gif|left|200px]]
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{{STRUCTURE_2b8v| PDB=2b8v | SCENE= }}
{{STRUCTURE_2b8v| PDB=2b8v | SCENE= }}
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'''Crystal structure of human Beta-secretase complexed with L-L000430,469'''
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===Crystal structure of human Beta-secretase complexed with L-L000430,469===
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==Overview==
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We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC(50)=35 nM. The synthesis and biological activities of these compounds are described.
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(as it appears on PubMed at http://www.pubmed.gov), where 16263281 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16263281}}
==About this Structure==
==About this Structure==
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[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Bace]]
[[Category: Bace]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:59:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:28:28 2008''

Revision as of 12:28, 27 July 2008

Template:STRUCTURE 2b8v

Crystal structure of human Beta-secretase complexed with L-L000430,469

Template:ABSTRACT PUBMED 16263281

About this Structure

2B8V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformationally biased P3 amide replacements of beta-secretase inhibitors., Stachel SJ, Coburn CA, Steele TG, Crouthamel MC, Pietrak BL, Lai MT, Holloway MK, Munshi SK, Graham SL, Vacca JP, Bioorg Med Chem Lett. 2006 Feb;16(3):641-4. Epub 2005 Nov 2. PMID:16263281

Page seeded by OCA on Sun Jul 27 15:28:28 2008

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